New undisclosed project created on 2019-11-19 submitted by: Cornell University In: Ithaca, US
Worldwide Provider of Clodronate Liposomes
Explaining The Mechanism of Clodronate Liposomes
Clodronate is not a toxic drug in itself and liposomes (if prepared of phosphatidylcholine and cholesterol) are not toxic either.
Free Clodronate will not easily pass phospholipid bilayers of liposomes and cell membranes but liposomes are eagerly swallowed by macrophages.
The implication is that Clodronate, once delivered into phagocytic cells using liposomes as vehicles, will not escape from the cell. After disruption of the phospholipid. bilayers of the liposomes under the influence of the lysosomal phospholipases in the macrophage, the drug, which is dissolved in the aqueous compartments between the liposomal bilayers, is released into the cell.
The Clodronate is accumulated intracellularly and after exceeding a threshold concentration, the cell is irreversibly damaged and dies by apoptosis (J. Immunol. Meth. 193: 93-99, 1996).
ORDER ONLINE
Easy online ordering via our web shop. We ship directly to our customers in the USA, Europe, Asia, Australia and Africa. For questions about ordering, please send us and email or fill in our contact form. One of our colleagues will be happy to provide assistance in your ordering process.
ABOUT CLODRONATE LIPOSOMES
Clodronate liposomes are suitable for depleting macrophages. After administration, macrophages ingest and digest the phospholipid bilayers of the liposome, whereas clodronate will accumulate in the cell and eventually eliminate the macrophage by initiating its programmed cell death.
BECOME A PARTNER
Our specialists have more than 30 years of knowledge and experience in developing liposomes. Are you a distributor and interested to become our business partner? Contact us for pricing and additional information, or apply for partnership via our contact form.
CONTACT US
Our team is always available to answer your questions. Please do not hesitate to contact us.
