Results

Sections of mouse liver, stained with monoclonal antibody F4/80 Normal liver with positive Kupffer cells

Liver of a mouse, 2 days after injection with clodronate-liposomes. Kupffer cells have been depleted

Sections of mouse spleen stained for acid phosphatase Normal spleen with positive splenic macrophages

Spleen of a mouse 2 days after injection with clodronate liposomes. Only few macrophages are left