About

ABOUT THE TEAM

liposoma-divisions-2-1-1.png
liposoma-divisions-2-1-3.png
liposoma-divisions-2-1-2.png
liposoma-divisions-2-1-4.png

Nico van Rooijen – Inventor of Clodronate Liposome Technology

Nico van Rooijen, a Dutch immunologist affiliated with the Vrije Universiteit Amsterdam, is renowned for pioneering the development of clodronate liposomes—a transformative tool in immunological research. His innovation has significantly advanced our understanding of macrophage functions and their roles in various diseases.


Nico’s groundbreaking work has left a lasting impact across immunology, oncology, nephrology, and neuroscience.

Clodronate Liposomes

This technology has enabled five key scientific breakthroughs:

  1. Selective macrophage depletion – For the first time, researchers could eliminate macrophages in living organisms to study their roles in health and disease.
  2. Anti-inflammatory applications – In addition to macrophages, clodronate liposomes modulate neutrophil activity, contributing to reduced inflammation.
  3. Reduction of organ fibrosis – In models of kidney injury, macrophage depletion led to less tissue scarring and improved organ function.
  4. Suppression of tumor growth and angiogenesis – By targeting tumor-associated macrophages, clodronate liposomes reduced cancer progression and blood vessel formation.
  5. Improved stem cell engraftment – Pre-treatment with clodronate liposomes enhanced hematopoietic stem cell transplantation by making the bone marrow niche more receptive.

Van Rooijen’s invention remains a cornerstone of immunological research. His legacy continues through Liposoma a company inspired by his work that distributes clodronate liposomes to research institutions worldwide.

Liposoma – Advancing Liposomal Technology Across Industries

Building on the legacy of Nico van Rooijen’s clodronate liposomes, Liposoma has evolved into a cutting-edge biotechnology company specializing in liposomal delivery systems. Liposomes—tiny, spherical vesicles made of phospholipid bilayers—serve as biocompatible carriers that can encapsulate both water-soluble and fat-soluble compounds. Their unique structure mimics cell membranes, making them ideal for safe and targeted delivery.

Liposoma utilizes this versatile platform to develop and manufacture liposome-encapsulated formulations for diverse sectors, including:

  1. Immunological Research
  • Clodronate liposomes, developed by Van Rooijen, remain a cornerstone product.
  • These liposomes are used in research to temporarily deplete macrophages, helping scientists understand immune responses and disease mechanisms.

 

  1. Medical Nutrition & Dietary Supplements
  • Liposoma creates liposomal formulations of vitamins and minerals.
  • Encapsulation enhances bioavailability, absorption, and stability, often outperforming traditional supplements.
  • These formulations are especially valuable in clinical settings or for individuals with absorption challenges.

 

  1. Pharmaceutical Development
  • Liposomes enable targeted drug delivery, reducing side effects and improving therapeutic outcomes.
  • Liposoma develops customized liposomal carriers for preclinical and clinical use, including for oncology, inflammatory diseases, and infectious diseases.
  • Their liposomes can be engineered for specific release profiles, tissue targeting, or immune evasion.

  1. Cosmetics and Dermatology
  • Liposomal encapsulation of active ingredients like hyaluronic acid, coenzyme Q10, or niacinamide improves skin penetration, efficacy, and moisture retention.
  • Liposoma develops formulations for brands aiming to deliver scientifically substantiated cosmetic benefits.

Scientific and Market Advantage

Liposoma differentiates itself through:

  • Deep R&D expertise rooted in academic science.
  • Proprietary formulation methods ensuring high encapsulation efficiency and product stability.
  • A focus on quality, safety, and compliance, enabling use in regulated markets.

INVESTORS & SUBSIDIES

Select your currency