Storage and Directions of Use
Upon arrival, liposomes should be stored between 4 – 8 ºC (or 39 – 47 ºF). The liposomal suspensions should never be frozen, nor be exposed to extreme high temperatures. This can cause disturbances to the phospholipid bilayers, possibly leading to leakage of clodronate out of the liposome.
Before administration, let the liposomes reach room temperature first and gently shake or stir the suspension. Liposomes tend to precipitate after some time, causing an inhomogeneous distribution in the vial. When injection takes too much time, the liposomes may even precipitate in the syringe. If multiple animals are injected using the same syringe, this can cause differential dosing.
Dilution of the suspension is discouraged, but if necessary use PBS or saline.
We advise our customers to use our liposomal formulation within 16 weeks after shipment. Use after the expiry date has occurred is strongly discouraged. After this period the risk of contamination increases, and a slight loss of function could occur.